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KMID : 0869619940110020111
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Journal of Korean Society of Hospital Pharmacists
1994 Volume.11 No. 2 p.111 ~ p.114
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The Dissolution Test and the Content Uniformity of Lithium Carbonate Tablet
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Abstract
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Lithium is indicated in the treatment of recurrent bipolor disorders and mania. Because lithium has a narrow therapeutic range, it needs therapeutic drug monitoring and dosage regimen through serum lithium concentration. The dissolution test and the content uniformity test are necessary to secure safety, efficacy and quality control. These tests were performed to compare their efficacy among preparations with same active ingredient and its amount. Those were used as a method in measuring bioavailability of each product. The materials were four lithium carbonate tablets which were made in four different manufacturers(A. B, C and D). the results were as follows. 1) The dissolution test was performed for an hour using paddle method, in the solution of distilled water and artificial gastric juice. Dissolution rates(%) for 30 minutes(D_(30)min-) of all products were more than 60%. 2) In the content uniformity test, all the content of products were more than 95%. The result showed a nonsignificant difference in the dissolution rate and the content uniformity.
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